cancer and curcumin

Chemotherapy is one of the most viable agents used for cancer treatment for many years even though it has its share of side effects. The most commonly used chemotherapeutic agent is a platinum-based drug. The first generation platinum agent like cisplatin offers great anticancer properties but its usage is limited due to its very serious side effects like neurotoxicity, nephrotoxicity, and ototoxicity. After rounds of research, a second-generation platinum drug called carboplatin was developed which was seen to have lesser serious side effects except for myelosuppression.

What is Myelosuppression?

This is a condition in which bone marrow activity decreases resulting in very few red blood cells, white blood cells, and platelets. Some of the common symptoms of myelosuppression are:

  • Easy bruising bleeding in the nose, gums, and mouth due to low platelets
  • Fever, chills, and rashes
  • Fatigue, pale skin, and nails due to low red blood cells count
  • Anemia

All the above symptoms are seen as the process of chemotherapy kills the important cells present in our blood. About 20-40% of patients who have been treated with conventional doses of carboplatin experience this kind of side effects. The main challenge has been to reduce the side effects of carboplatin on the overall health of the patient as it is a good chemotherapeutic agent.

Can Curcumin be of Some Assistance in Curbing the Side Effects of Carboplatin?

In cancer curcumin helps

Many studies have shown that curcumin does ac like a great anticancer agent when used in combination with carboplatin. Curcumin is a natural polyphenol that has been used since time immemorial as a great anti-inflammatory agent that prevents the proliferation of tumour cells. Curcumin is known to show significant antiproliferative and apoptotic effects in many tumour cells. Since curcumin is also a good antioxidant agent, it inhibits the formation of reactive oxygen species.

An experiment was carried out when the C57B6 mice were injected with T241 fibrosarcoma cells. The division was done in such a way that four groups of mice were treated with a series of intraperitoneal injections of 20% Tween 80 ( control), only curcumin, only carboplatin, or a combination of curcumin and carboplatin. The results showed that the inhibitory effects on tumour volume seen in the mice treated with combined drugs were stronger than that of the other two groups of control and carboplatin group. This means that curcumin has the ability to attenuate the side effects which are induced by carboplatin to improve the survival of cancer patients.

How does Curcumin help in Reducing the Side Effect of Carboplatin?

It was also seen that treatment with curcumin and carboplatin can significantly help to improve carboplatin-induced bone marrow damage by helping the reappearance of bone trabecular and defibrillation hematopoietic cells. Curcumin also improves DNA damage induced by the use of carboplatin in bone marrow cells. In other words, we can say that it helps in the DNA repair pathway.  Lesions in the DNA caused by the use of platinum drugs were repaired by a combination of homologous recombination and nucleotide excision repair. One of the major side effects of carboplatin treatment is nephrotoxicity wherein the kidney accumulates a very high concentration of cisplatin as compared to any other organ.

To be specific, it affects the terminal part of the proximal tubule and the distal nephron leading to either necrosis or apoptosis. As mentioned above, curcumin prevents the formation of free radicals, thus reducing platinum-based drugs related to the production of ROS. By increasing the tolerance of bone marrow cells to chemotherapy-induced toxicity, curcumin can tackle the side effects of this second generation of the platinum agent. It is also known to reduce the cisplatin-induced clastogenesis by acting as a scavenger of free radicals.

Leave a Reply

Your email address will not be published. Required fields are marked *

Clinical Trial & Our Product

Since health care & medicine is an industry, formulations are controlled through intellectual property rights denying easy access to common people and maintaining the buoyancy for the interest holders. Formula’s can be patented and that covers business interests that drive innovations these days.

So instead of conducting trials on the raw root, almost all companies promote clinically tested formulations of extracts to make it appear better then how the phytochemical was in its original state. Its like extracting an important organ from the body and then putting it on support system, expecting it to perform better in insolation then how it could perform when in it was in its natural form. The truth is, that the best way to consume a plant based medicine is in its raw form. Curcumin is one of the active ingredients in the root Curcuma Longa.

Since its more important to know what your food ate then what you ate, its important to know that the supplements you are using based on curcumin has curcumin from a gene modified variety of curcuma longa which suffers from an imbalance of every other mineral. You see a plant also behaves how a human body behaves when it is injected with steroids to gain muscle mass for body building purpose. The plants have higher levels of curcumin but all other secondary minerals found along curcumin in the plant get compromised as the plant can not feed all nutritions equally when it is designed to feed most of its nutrition towards developing higher levels of curcumin. It has severe side effects on the health of the plant and apparently on the people consuming such plants or extracts coming from these plants. However marketing and promotions have evolved to divert attention very wisely.

An extract of any herb can never be stored in its original state and hence needs base agents, preservatives which hardly leave it how it must be. We believe that access to medicine and healthcare is a basic right of every human and animal living on planet earth. Hence we do not first extract and then add preservatives or agents like pepperine to make the extract bio-available. This is the reason we never patent any of our products. We instead hand process the whole root we cultivate in our farms and share it with the people under different brand names for different health conditions based on the concentration of minerals present at testing. You can also buy the seed from us and cultivate it but it will certainly not be as potent as you get from us.

How potent is the active ingredient in the plant depends on the quality of seed, soil, water and environment. Our products work far better then most of the curcumin based supplements globally being used for Therapeutic benefits.

We do not intend to formulate or patent our products. So instead of choosing a supplement with an extract, choose wisely and go for the best and not the Cheapest.

All our products are cultivated, harvested, hand processed and distributed directly from our own farms to ensure that people who depend on our products for their acute and chronic problems get consistent supply of highest quality, ultra premium, medicinal grade, Non-GMO, Indigenous, Naturally enriched with curcumin, Wild Strand curcuma longa powder for therapeutic benefits. We cultivate this in the middle of a national park which happens to be the best breeding ground for Bengal tigers in India called Bandhavgarh.